香草醛水杨酰腙的合成

The Systhesis of Vanillin Salicylic Acyi Hydrazone

以水杨酸甲酯与80%的水合肼为原料,制备水杨酰肼,然后以冰醋酸为催化剂,通过水杨酰肼与香草醛的缩合反应,合成了香草醛水杨酰腙。测定了产物的熔点,并用红外光谱对产物香草醛水杨酰腙的结构进行了表征。研究了反应温度、加热回流时间和反应物投料比对产率的影响,并测定其抑菌活性。结果表明:在温度65℃,加热回流时间2h和原料水杨酰肼与香草醛摩尔比为1∶1.4的条件下,产品产率高达73.4%。

Salicylic hydrazide was preparation through methyl salicylate and 80%of hydrazine hydrate, vanillin salicylic acyl hydrazone was synthesized through salicylic hydrazide and vanilla aldehyde condensation reaction, with glacial acetic acid as catalyst, vanillin salicylic acyl hydrazone structures have been characterized by determining the melting point of the product and infrared spectrum. The effect of the heating reflux time, reaction temperature and reactant ratio on the yield was studied, its bacteriostatic activity of staphylococcus aureus were tested. Results show that the temperature is 65℃, time of heating reflux is 2h and raw material salicylic hydrazide and vanillin mole ratio is 1∶1.4, the yield can be as high as 73.4%.