小儿肺炎支原体感染后免疫功能的变化规律及其临床意义

Study on change and clinical significance of immune function in children infected with Mycoplasma pneumoniae

目的探讨小儿肺炎支原体感染后免疫功能的变化规律及其临床意义。方法选取2008年8月至2013年11月肺炎支原体感染患儿106例作为实验组,选取同期体检健康的小儿106作为对照组,对两组的血清免疫球蛋白(Ig A、Ig M、Ig G)和补体C3、C4红细胞免疫状态(免疫复合物花环率、C3b受体花环率、免疫粘附促进以及抑制因子)、外周血的T淋巴细胞亚群(CD3+、CD8+、CD4+和CD4/CD8)水平进行检测。结果实验组患儿急性期免疫球蛋白、红细胞免疫的水平及外周血的T淋巴细胞亚群均低于对照组,恢复期两组上述差异依然存在,仅差异幅度变小(P<0.05);急性期和恢复期相比,差异也有统计学意义(P<0.05)。结论小儿受到肺炎支原体感染后免疫功能都是处于低下的状态,改善免疫状态,对于改善疾病的状态具有积极的作用。

Objective To investigate the clinical significance and changes of immune function in children infected with Mycoplasma pneu-moniae（M. pneumoniae）. Methods From August 2008 to November 2013,106 cases of children with M. pneumoniae infection were selected as experimental group,106 healthy children were as control group. Serum levels of IgA,IgM,IgG,complement C3 and C4 ,red blood cell im-mune status（ immune complex rosette,C3b receptor rosette,immune adhesion promoting and inhibiting factors）,and peripheral blood T lympho-cyte subsets（CD3 ^＋,CD8 ^＋,CD4^ ＋ and CD4/CD8）were detected in both groups. Results The immune globulin,red cell immune level and peripheral blood T lymphocyte subsets in the experimental group were lower than those in the control group in both acute phase and recovery phase of the infection（ P 〈0. 05）,and these differences between the acute phase and recovery phase of the infection were also statistically significant（ P 〈0. 05）. Conclusion The immune function is inhibited during M. pneumoniae infection and the improvement of immune status may play a positive role in the treatment of the infection.