卡马西平联合塞来昔布治疗癫痫模型大鼠的不良反应评估

Assessment of the adverse reactions of carbamazepine combined with celecoxib in induced epileptic rat model

目的评估卡马西平联合塞来昔布治疗癫痫模型大鼠的不良反应。方法雄性Wistar大鼠分为假手术组、对照组及实验组,对照组及实验组以海仁酸点燃建立癫痫模型,分别给予生理盐水及卡马西平与塞来昔布联合治疗。结果治疗后3组大鼠胃窦黏膜及肾脏组织病理变化无显著差异(P>0.05);凝血功能国际标准化比值(INR)无显著差异(P>0.05);对照组及实验组心肌肌钙蛋白T(cTnT)水平显著高于假手术组(P<0.01),且实验组显著低于对照组(P<0.05)。结论卡马西平联合塞来昔布对癫痫模型大鼠的胃窦黏膜、肾脏组织、凝血功能及心肌功能均无显著不良反应,具有较高的安全性。

Objective To assess the adverse reactions of carbamazepine combined with celecoxib in treatment of induced epileptic rats.Methods Male Wistar rats were divided into sham group,control group and experimental group.Kainic acid induced epilepsy model was established and normal saline or carbamazepine combined with celecoxib were given individually to the control group and the experimental group.Results After treatment,the pathological changes of gastric antrum mucosas and kidney tissues among three groups showed no significant differences （P 〉 0.05）.Coagulation international normalized ratio （INR） showed no differences among three groups （P 〉 0.05）.The cardiac troponin T （cTnT） levels in the control and experimental groups were obviously higher than those in sham group （P 〈 0.01）.Moreover,the cTnT level in the experimental group was lower than that in the control group （P 〈 0.05）.Conclusion There were no significant adverse reactions of carbamazepine combined with celecoxib in gastric antrum mucosa,kidney tissue,coagulation and cardiac function of induced epileptic rats.