阿魏酸钠注射液对冠心病患者血脂、血浆一氧化氮和血管内皮素-1的影响

Influence of sodium ferulate injection on levels of blood lipid,nitric oxide and endothelin-1 in patients with coronary heart disease

目的观察阿魏酸钠注射液对冠状动脉性心脏病(冠心病)患者血脂、血浆一氧化氮(NO)及内皮素-1(ET-1)的影响。方法 80例冠心病患者随机分为观察组42例和对照组38例。对照组给予降血脂、抗血小板聚集、改善微循环等常规治疗,观察组加用阿魏酸钠注射液静脉滴注。检测治疗前、后2组患者血脂、血浆NO和ET-1水平。结果观察组总有效率92.86%,显著高于对照组的73.68%(P<0.05);治疗后2组血脂水平改善显著(P<0.05或P<0.01),且观察组显著优于对照组(P<0.05或P<0.01);治疗后2组血浆NO水平显著升高(P<0.01),ET-1水平显著降低(P<0.01),且2组间比较差异显著(P<0.01)。结论阿魏酸钠注射液治疗冠心病疗效确切,可显著升高血浆NO表达水平和降低ET-1水平,保护血管内皮功能。

Objective To investigate the influence of sodium ferulate injection on levels of blood lipid,nitric oxide （NO） and endothelin-1 （ET-1） in patients with coronary heart disease （CHD）.Methods A total of 80 patients with CHD were randomly divided into observation group （n =42） and control group （n =38）.Conventional treatment including Anti-hyperlipidemia,antiplatelet aggregation and microcirculation improvement were given to both groups,and addition intravenous drip of sodium ferulate was administrated in observation group.The blood lipid,nitric oxide （NO） and endothelin-1 （ET-1） were detected before and after treatment.Results Overall response rate was 92.86 % in observation group and 73.68 % in control group （P 〈 0.05）.Levels of blood lipid were improved in both groups after treatment and significantly different between groups （P 〈 0.05,P 〈 0.01）.patients achieved more increased plasma NO and decreased ET-1 compared to those in control group （P〈0.01）.Conclusion Findings indicates the effects of sodium ferulate injection,which can protect the vascular endothelial function.