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阿托伐他汀对糖尿病大鼠胸主动脉TLR4表达影响的实验研究 被引量：2

Experimental Study of the Effect of Atorvastatin on the Expression of TLR4 in Aorta Thoracalis of the GK Mice
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摘要 目的观察GK大鼠胸主动脉TLR4表达及应用阿托伐他汀其表达水平的变化。探讨TLR4与动脉硬化的关系。方法分组:空白对照组;实验对照组;阿托伐他汀组,5周后应用RT-PCR、Western blot检测各组大鼠胸主动脉TLR4表达。结果实验对照组较空白对照组TLR4表达显著增高,阿托伐他汀组较实验对照组TLR4表达显著降低。结论阿托伐他汀可能通过降低TLR4表达,防治动脉粥样硬化。 Objective To observe the expression of TLR4 in aorta thoracalis of the GK mice and the change of that after using atorvastatin. Methods Mice were divided into control group, experimental control group, atorvastatin group. After five weeks, TLR4 was detected by using PT-PCR and Western blot method. Results The TLR4 level of experimental control group is higher than that of control group. The TLR4 level of atorvastatin group is lower than that of experimental control group（P〈 0.01）. Conclusions Atorvastatin may prevent atherosclerosis through reducing TLR4 expression.
作者 朱晓莹 李昭 胡健
机构地区 辽宁省本溪市本钢总医院心血管内科 中国医科大学附属第一医院心血管内科
出处 《中国医药指南》 2014年第36期19-19,共1页 Guide of China Medicine
关键词 TLR4 阿托伐他汀 糖尿病 动脉硬化 TLR4 Atorvastatin Diabete Atherosclerosis
分类号 R587.1 [医药卫生—内分泌]
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参考文献4

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共引文献37

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中国医药指南
2014年 第36期

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