多糖生物医用胶对创面修复作用的研究

Wound Healing of Polysaccharide Medical Biological Glue on Back Wound Rat in Vivo

目的观察多糖生物医用胶促进创面组织再生、创面修复的作用。方法 SD大鼠,♀♂各半,分为聚维酮碘组、多糖生物医用胶组及生理盐水组。大鼠右侧背部利用电烙铁烫伤方式,使皮肤造成直径为2 cm的圆形深Ⅱ度烫伤创面。用透明膜标记法记录伤后3,7,14,28 d创面面积,7,14,28 d取创面修复组织作病理学观测,考察多糖生物医用胶对创面修复的影响。结果与生理盐水组比较,多糖生物医用胶组在伤后7,14,28 d创面面积显著减少(P<0.05)。病理组织学检查显示在创伤修复过程中多糖生物医用胶组明显改善组织新生及促进组织修复。结论多糖生物医用胶对创面修复具有一定的改善作用。

OBJECTIVE To investigate the wound healing of biological medical glue ameliorating wound tissue regeneration and wound healing. METHODS The healthy SD rat were allowed into 3 group as follows： polysaccharide medical biological glue group, saline group, povidone iodine solution group. The model were record after injury 3, 7, 14 and 28 d wound area, and the wound repair tissue were carried out pathological check at 7, 14 and 28 d. RESULTS After injury 7, 14, 28 d, the wound area in polysaccharide biological medical glue group were significantly decreased（P0.05）. HE staining showed that polysaccharide biological medical glue could promote the wound healing pathological process, fibroblasts in the polysaccharide biological medical glue group generally increased significantly. CONCLUSION Polysaccharide biological medical glue can promote the wound healing in rat.