原发性肝癌根治性切除术后骨转移的危险因素分析

Analysis of risk factors for bone metastasis in patients with primary hepatocellular carcinoma after radical resection

目的探讨原发性肝癌根治性切除术后骨转移的危险因素。方法回顾性分析2005年1月至2012年12月我院349例原发性肝癌行根治性手术治疗患者的临床资料。结果术后随访期内出现骨转移43例。甲胎蛋白(AFP)>400mg/mL、肿瘤数目、肿瘤大小、微血管侵犯对于原发性肝癌根治性手术治疗后是否出现骨转移的差异有统计学意义。Logistic回归分析显示,AFP>400mg/mL、肿瘤数目、微血管侵犯是原发性肝癌根治性切除术后骨转移的独立影响因素。结论对于术前AFP升高、肿瘤多发以及存在微血管侵犯的患者,术后容易出现骨转移,需密切随访。

Objective To explore the risk factors for bone metastasis in patients with primary hepatocellular carcinoma after radical resection.Methods The clinical data of 349 patients with primary hepatocellular carcinoma after radical resection were retrospectively analyzed.Results Atoal of 43 patients had bone metastasis after radical resection during the follow-up period.The incidences of bone metastasis after radical resection were closely related to AFP〉400mg/mL,the number of tumor,the tumor size and microvascular invasion.Multivariate analysis demonstrated that AFP〉400 mg/mL,the number of tumor and microvascular invasion were independent risk factors for bone metastasis after radical resection.Conclusion Patients with elevated AFP preoperative,numerous tumors and microvascular invasion may develop into bone metastasis,and close follow-up was therefore necessary.