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维生素D受体基因Fok I位点单核苷酸多态性与溃疡性结肠炎的关系 被引量：3

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摘要 目的:分析维生素D受体(VDR)基因Fok I位点单核苷酸多态性与溃疡性结肠炎(UC)的相关性。方法:收集192例UC患者和288例对照者,采用直接测序法检测Fok I基因多态性。结果:与对照组相比,UC组中Fok I位点的突变等位基因(C)和基因型(CC)的频率明显降低(P=0.004、0.018)。按病变部位分层分析,远端结肠炎UC患者中Fok I位点的突变等位基因(C)和基因型(CC)频率明显高于广泛性结肠炎患者(P=0.011、0.031)。结论:Fok I基因突变不仅降低UC的患病风险,还可能影响病变部位。
作者 蓝德云 焦军强 李平 陶学育
机构地区 泰顺县人民医院内科
出处 《实用医学杂志》 CAS 北大核心 2014年第24期3955-3957,共3页 The Journal of Practical Medicine
基金 温州市科技局课题(编号:Y20130049)
关键词 溃疡性结肠炎 维生素D受体 基因多态性
分类号 R574.62 [医药卫生—消化系统]
  • 相关文献

参考文献10

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共引文献1

同被引文献29

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引证文献3

二级引证文献13

实用医学杂志
2014年 第24期

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