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肝硬化相关性免疫功能障碍的研究进展 被引量:8

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摘要 肝硬化相关性免疫功能障碍综合征(CAIDS)[1]是以肝硬化患者清除循环中细胞因子、细菌和内毒素能力下降为特点的获得性全身免疫功能障碍及紊乱状态,免疫功能随着病程和疾病的进展而恶化。患者防御能力的缺陷将导致感染风险的增加。一旦感染,促炎症细胞因子和血流动力学紊乱将导致严重后果,出现系统性炎症反应综合征(SIRS)和败血症,继而可引起急性或慢性的肝功能恶化、感染性休克、肾功能衰竭、肝性脑病和凝血功能紊乱。甚至多器官功能衰竭和死亡[2].确切地来说.肝硬化患者是处于免疫功能抑制与过度激活并存的紊乱状态。
机构地区 北京解放军第
出处 《实用医学杂志》 CAS 北大核心 2014年第24期4049-4050,共2页 The Journal of Practical Medicine
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