藏药鲜卑花化学成分研究

Chemical constituents of Tibetan herbal medicine Sibiraea laevigata

目的对鲜卑花Sibiraea laevigata化学成分进行研究。方法利用硅胶柱色谱和中压制备等方法进行分离纯化,并经核磁共振、质谱等波谱手段确定化合物结构。结果从鲜卑花嫩叶和果序的乙醇提取物中分离得到12个化合物,分别鉴定为月桂酸甘油酯（1）、正壬烷（2）、3,4-二羟基反式肉桂酸乙酯（3）、异阿魏酸（4）、甲基阿魏酸（5）、对甲氧基桂皮酸（6）、ω-羟基-3-甲氧基-4-羟基苯乙酮（7）、3-羟基-1-（4-羟基-3,5-二甲氧基苯）-1-丙酮（8）、（＋）-松脂素（9）、bis（2-ethylhexyl）phthalate（10）、9α-hydroxymedioresinol（11）、C-veratroylglycol（12）。结论化合物1~12均为首次从鲜卑花中发现,化合物9~12为首次从鲜卑花属中得到。

Objective To study the chemical constituents from Sibiraea laevigata. Methods The compounds were isolated by column chromatography and their structures were elucidated through spectroscopic analysis（NMR）. Results Twelve compounds were isolated and identified with spectral analysis and compared with authentic samples as lauric acid 1-monoglyceride（1）, n-nonane（2）, ethyl caffeate（3）, isoferulic acid（4）, methyl ferulic acid（5）, p-methoxy cinnamic acid（6）, ω-hydroxypropiovanillone（7）, 3-hydroxy-1-（4-hydroxy-3, 5-dimethoxyphenyl）-1-propanone（8）,（＋）-pinoresinol（9）, bis（2-ethylhexyl） phthalate（10）, 9α-hydroxymedioresinol（11）, and C-veratroylglycol（12）. Conclusion All compounds are found from the plant for the first time, and compounds 9—12 are found from the plants of Sibiraea Maxim. for the first time. The results provide the new chemical evidences for the bioactive investigation of this plant.