未分化关节炎162例抗CCP抗体检测及3年随访分析

A three year follow up study of anti-CCP(cyclic citrullinated peptide) antibody determination of 162 patients with undifferentiated arthritis

目的了解未分化关节炎(undifferentiated arthritis,UA)的抗CCP检测情况及发展规律。方法分析162例UA患者抗CCP检测情况及3年随访结果。结果 1首诊检测抗CCP抗体阳性率为4.3%;2病程中双手近端指间及足腕关节疼痛最多见;33年随访结果:42例仍为UA,58例症状消失;另外62例转归为类风湿关节炎(RA)、骨性关节炎(OA)、强直性脊柱炎(AS)、系统性红斑狼疮(SLE);43年内抗CCP检测阳性率上升明显,3年后上升为14.8%;53年中抗CCP抗体阳性患者全部确诊RA,RA患者抗CCP抗体阳性率52.2%。结论 UA是一组常见的关节炎,部分患者可进展为RA、OA、AS及SLE等其他疾病。对UA患者应定期进行抗CCP抗体检测,有助于类风湿关节炎的早期诊断。

Objective To investigate the determination of anti-CCP and the law of development of undifferentiated arthritis （UA）. Methods 162 UA patients were registered in rheumatology outpatient clinic of Jincheng People＆#39;s Hospital. The determination results of anti-CCP and 3-year follow-up data of them were collected and analyzed. Results ①4.3%were anti-CCP positive in the initial diagnosis.②The chief symptoms of 162 UA patients were hands proximal interphalangeal pain and foot wrist pain. ③In three years 162 cases developed to 46 cases rheumatoid arthritis（RA）,8 osteoarthritis（OA）,5 ankylosing spondylitis（AS）,3 systemic lupus erythematosus（SLE）,42 UA,58 cases with symptomatic disappeared.④In 3 years the positive rates of anti-CCP had dramatically increased, and reached to 14.8%after 3-year follow-up. ⑤In three years, the anti-CCP positive patients all have been confirmed RA, and the positive rates of anti-CCP of RA was 52.2%. Conclusion UA were a group of a variety of arthritis, some patients can progress to RA, OA, AS and SLE, and other rheumatism. Close follow-up on the patients, especially anti-CCP positive patients, and regular anti-CCP determination conduce to early diagnosis of RA.