烘制法对不同质地蒙药草乌炮制效果的比较研究

Comparative study of effectivenesses of baking method on Aconiti kusnezoffii of different qualities

目的观察烘制法对不同质地蒙药草乌的降毒作用。方法草乌用水浮法,按密度和大小分档烘制,用HPLC方法,测定总单酯型生物碱和总双酯型生物碱质量。结果烘制沉品直径大于1 cm、小于1 cm与烘制浮品直径大于1cm、小于1 cm样品总单酯型生物碱质量分别为0.39%,0.38%,0.19%,0.21%,总双酯性生物碱质量分别为0.18%,0.19%,0.29%,0.29%。结论烘制法炮制蒙药草乌降毒效果与草乌质地相关,建议按其密度、大小分档后再进行烘制。

Objective To observe detoxifying effectivenesses of baking method on Aconiti kusnezoffii of different qualities and provide evidence for preparation standardization of Aconiti kusnezoffii of traditional Mongolian medicine.Methods Water flotation method is used to bracket the Aconiti kusnezoffii according density,and then bracket according size.The total diester alkaloids quality and total monoester Alkaloid quality were determined according to the high efficiency liquid chromatography method.Results The Braked products Aconiti kusnezoffii diameter above1 cm（ B- 1）,below 1cm（ B- 2）,are prepared by baking method,and the sample of total monoester alkaloids contents are 0.39%,0.38%,0.19%,0.21% respectively; the total diester alkaloids contents are0.18%,0.19%,0.29%,0.29%.Conclusion Use the baking method processing drugs effectiveness of Aconiti kusnezoffii are related with their quality.To suggest bracket the Aconiti kusnezoffii according density and size before preparing Aconiti kusnezoffii of traditional Mongolian medicine by baking method.