急性移植物抗宿主病的病理生理学和治疗药物的研究状况

Development of actue graft - versus - host disease in pathophysiology and medications

造血干细胞移植在临床上是一种有效的、广泛的治疗恶性和非恶性的血液系统和某些实体瘤的治疗手段。然而,急性移植物抗宿主病(a GVHD)作为一种移植后的并发症,严重影响了移植的成功率,由此产生了巨大的发病率和致死率。本文主要介绍a GVHD的病理生理学机制和前景药物在预防和治疗a GVHD的作用机制。

Hematopoietic stem cell transplantation is an efficient and widely treatment modality in the clinic for the malignant and nonmalignant hematopoietic disorders or some solid tumors.Unfortunately,acute graft- versus- host disease（ GVHD） become the big complication after posttransplantation,and poorly influence the success rates for transplantation,thus induce the great morbidity and lethality.In this review,we main introduce the pathophysiology of acute GVHD and the mechanisms of perspective drugs.