血清降钙素原与C-反应蛋白水平在检测恶性肿瘤患者感染性疾病中的应用评价

Effectiveness of determination of levels of serum procalcitonin and C-reactive protein in diagnosis of infections in malignant tumor patients

目的探讨血清降钙素原(PCT)与C-反应蛋白(CRP)水平检测在恶性肿瘤患者感染诊断中的应用评价。方法选取医院2012年1月-2013年1月收治的50例恶性肿瘤感染患者作为观察组及26例恶性肿瘤非感染患者作为对照组,采用荧光免疫分析法和免疫比浊法分析两组患者的PCT、CRP及其阳性率。结果两组患者经过治疗后,观察组患者的PCT、CRP分别为(18.37±20.12)ng/ml、(46.49±32.52)mg/L,而对照组分别为(0.32±0.23)ng/ml、(5.14±5.29)mg/L,两组比较差异有统计学意义(t=4.560,6.419;P<0.05);两组患者经过治疗后,观察组患者的PCT、CRP的阳性率为92.0%、84.0%,对照组分别为11.5%、15.4%,两组比较差异有统计学意义(χ2=48.347,P<0.01;33.707,P<0.01)。结论 PCT与CRP均可作为患者早期感染的重要指标,而PCT水平还可对早期诊断、预后具有重要意义,值得临床推广使用。

OBJECTIVE To observe the effectiveness of determination of the levels of serum procalcitonin （PCT） and C-reactive protein （CRP）in diagnosis of infections in the malignant tumor patients.METHODS From Jan 2012 to Jan 2013,totally 50 malignant tumor patients complicated with infections were assigned as the observation group,and 26 malignant tumor patients without infections were set as the control group;the immunofluorescence assay and immunoturbidimetry assay were performed to analyze the levels of PCT and CRP as well as their positive rates.RESULTS After the treatment,the PCT level of the observation group was （1 8 .3 7 ± 2 0 .1 2 ）ng/ml,the control group （0 .3 2 ± 0 .2 3 ）ng/ml;the CRP level of the observation group was （4 6 .4 9 ± 3 2 .5 2 ）mg/L,the control group （5 .1 4 ± 5 .2 9 ）mg/L,there was significant difference between the two groups （t=4 .5 6 0 ,6 .4 1 9;P〈0 .0 5 ）.After the treatment,the positive rate of PCT was 9 2 .0% in the observation group,1 1 .5% in the control group;the positive rate of CRP was 8 4 .0% in the observation group,1 5 .4% in the control group,there was significant difference between the two groups （χ^2=4 8 .3 4 7 ,P〈0 .0 1;3 3 .7 0 7 ,P〈0 .0 1 ）.CONCLUSION Both PCT and CRP can serve as important indicators for the early infections,and the PCT level has great signifi-cance in the early diagnosis and prognosis,which is worthy to be promoted in the hospital.