重症肌无力患者术后肌无力危象发生率及其影响因素

STUDY ON PREVALENCE OF MYASTHENIA CRISIS AFTER SURGERY IN PATIENTS WITH MYASTHENIA GRAVIS AND ITS INFLUENTIAL FACTORS

目的研究重症肌无力(MG)患者术后肌无力危象的发生现状,探讨肌无力危象的相关影响因素。方法收集该院2011年2月—2014年2月收治的MG患者236例作为研究对象,对其采用MGFA分型法进行病情的评估,术后将切除组织送病理分析明确胸腺病理类型。结果 MG患者术后肌无力危象发生率为14.41%(34/236);不同性别患者年龄差异无统计学意义(P>0.05);不同性别、年龄段患者肌无力危象发生率差异无统计学意义,P>0.05;MG患者MGFA分型越高,发生肌无力危象的可能性越大(P<0.05);术后感染、胸腺病理类型均是患者肌无力危象发生的影响因素(P<0.05)。结论医务人员应全面评估MG患者胸腺切除术后肌无力危象的发生的风险,术前纠正诱发肌无力危象的相关危险因素,改善预后。

Objective To study the prevalence of myasthenia gravis （MG） crisis in patients with myasthenia gravis and explore the related affect factors .Method We collected 236 cases of patients with MG as the research subjects from February 2011 to February 2014 .MGFA classification method was used to assess the patients＇condition .The pathological types of thymus tissus were confirmed by a pathological analysis after operation .Results The incidence of myasthenia gravis crisis in MG patients after operation was 14 .41% （34/236） .The age difference between different gender had no statistically significant , P〉0 .05 . There was no statistically significant difference in patients with different gender ,age ,the incidence of my‐asthenia crisis ,P〉0 .05 .Higher the MGFA classification was ,the more chance of myasthenia crisis oc‐curred ,P〈0 .05 .Postoperative infection ,thymus pathological types were the influencing factors of myas‐thenia crisis ,P〈0 .05 .Conclusion Medical staff should comprehensive assess MG patients＇risk of the oc‐currence of myasthenia crisis after operation ,and correct the related risk factors of myasthenia crisis in pre-operation and improve the prognosis .