高危型HPV感染对妊娠期影响的探讨

The effect of high-risk human papillomavirus on pregnancy

目的探讨高危型人乳头瘤病毒（HPV）对妊娠及胎儿的影响。方法选取HC-Ⅱ分型检测法检测的62例高危型HPV感染孕妇以及同时期的62例非感染健康孕妇作为研究对象。比较分析妊娠早期、中期的流产率、胎膜早破率，以及妊娠晚期的早产率、胎儿发育迟缓率、死胎率、畸形率、新生儿窒息率等。结果结果显示，感染组妊娠早、中、晚期不良妊娠结局发生率（22．6％、14．5％、33．9％）均高于对照组（1．6％、1．6％、8．1％）（P〈0．05）。结论HPV的感染并非只通过性传播，还可能通过垂直传播，并且对妊娠和胎儿产生一定的负面影响。

Objective To investigate the effect of high-risk human papillomavirus （HPV） on pregnant women and fetuses. Methods 62 pregnant women with high-risk HPV infection detected by HC- Ⅱ genotyping assay and 62 non-infected healthy pregnant women were selected as the research object. Compared early and mid pregnancy abortion rate, premature rupture rate, premature birth rate in late pregnancy, fetal growth retardation rate, stillbirth rate, deformity rate, asphyxia rate of two groups. Result The incidences of adverse pregnancy outcomes in early, mid and late pregnancy of infection group were significantly higher than those of control group （22.6% vs. 1.6%, 14.5% vs. 1.6%, 33.9% vs.8.1%）（P 〈 0.05）. Conclusion HPV infection is not only transmitted through sex, but also through vertical transmission, impacting pregnant women and fetuses negatively.