摘要
目的观察NT—proBNP在呼吸衰竭及慢性肺源性心脏病合并呼吸衰竭患者中的水平变化，评价NT—proBNP对呼吸衰竭、呼吸衰竭并慢性肺源性心脏病的严重程度、预后评估的价值。方法选择2012年1月至2013年12月我科收治的55例呼吸衰竭患者，50例呼吸衰竭并慢性肺心病患者。测定人院时NT—proBNP血清浓度，比较两组患者NT—proBNP数值变化，再次以NT—proBNP2000pg／ml为截点，分为两组fA组为浓度高者，B组为浓度低者），观察两组患者住院天数、8个月内不良事件发生数。结果呼吸衰竭并慢性肺心病患者NT—proBNP水平湿著高于呼吸衰竭患者，差异有统计学意义（P〈0．05），NT—proBNP≥2000pg／ml组8月内不良事件发生率高，差异有统计学意义（P〈0．01）。结论NT—proBNP水平变化对呼吸衰竭、慢性肺源性心脏病诊断及预后有一定的临床评价意义。
Objective To observe serum NT-proBNP level in patients with respiratory failure （RF） and patients with RF combined with chronic cor pulmonale, investigate the value of NT-proBNP in evaluation of severity and prognosis in RF and RF combined with chronic cor pulmonale. Methods 55 cases of RF and 50 cases of RF combined with chronic cor pulmonale in our department from Jan. 2012 to Dec. 2013 were selected. Tested and compared serum NT-proBNP concentration in two groups. All patients were divided into two groups according to serum NT-proBNP concentration （group A： serum NT-proBNP concentration ≥ 2000 pg/ml; group B： serum NT-proBNP concentration 〈 2000 pg/ml）. Hospitalization day and the incidence of adverse events within 8 months were compared between two groups. Results Serum NT-proBNP concentration in patients with RF combined with chronic cor pulmonale was significantly higher than that in patients with RF （P 〈 0.05）. The rate of adverse events within 8 months in group A was significantly higher than that in group B （P 〈 0.01）. Conclusion Serum NT-proBNP concentration is helpful for diagnosis and prognosis evaluation for RF and chronic cor pulmonale.
出处
《国际医药卫生导报》
2015年第2期171-173,共3页
International Medicine and Health Guidance News
基金
中山市医学科研基金项目（20122A105）
