慢性肾功能衰竭贫血患者红细胞分布宽度与促红细胞生成素水平的相关性研究

The correlation analysis between red blood cell distribution width and serum erythropoietin level in patients with chronic renal failure and anemia

目的探讨慢性肾功能衰竭（CRF）贫血患者红细胞分布宽度（RDW）与其红细胞生成素（EPO）水平的相关性。方法将76例CRF贫血患者分为RDW≥13．0％组（n=43）和RDW〈13．0％组（n=33），用免疫学方法和生物检测技术测定CRF患者EPO、血色素、白蛋白、血清铁等指标，并对结果进行统计分析。结果RDW≥13．0％组肾胜贫血患者的EPO水平较RDW〈13．0％组相对低[O／P比值：（0．351±0．12）vs．（0．167±0．57），P〈0．01]，并且RDW与血清Alb、Fe水平呈负相关（r=-0．42，-0．37）。结论RDW可以作为监测CRF贫血患者EPO水平的预测指标，高水平的RDW提示CRF患者EPO水平相对较低。

Objective To investigate the correlation between red blood cell distribution width （RDW） and serum erythropoietin （EPO） level in patients with chronic renal failure （CRF） and anemia. Methods 76 patients with CRY and anemia were divided into RDW ≥ 13.0% group （n=43） and RDW 〈 13.0% group （n=33）. EPO, hemoglobin, Alb and serum Fe were detected in two groups by immunological methods and measurement for biotechnique, and then statistical analysis was performed. Results Serum EPO level in RDW≥13.0% group was significantly lower that in RDW 〈 13.0% group [（0.351 ± 0.12） vs.（ 0.167 ± 0.57）, P 〈 0.01]. RDW level was negatively correlated with serum Alb and Fe levels （r=-0.42,-0.37）. Conelusions RDW can be regarded as a predictive marker to monitor EPO level in patients with CRF and anemia. High RDW level indicates low EPO level in patients with CRF.