摘要
建立了高效液相色谱法测定萘普西诺及其对映异构体。采用Chiralpak AD—H色谱柱，以正己烷：异丙醇（95：5）为流动相，检测波长232nm。萘普西诺在0．015～20μg／ml范围内线性关系良好。萘普西诺与其R-异构体分离良好，回收率为99．4％和96．2％，RSD为0．61％和8．1％。
An HPLC method was established for the determination of naproxcinod and its enantiomer. A Chiralpak AD-H column was used with the mobile phase ofhexane ： isopropanol （95 ： 5） at the detection wavelength of 232 nm. It was linear for naproxcinod in the range of 0.015 - 20 μg/ml. Naproxcinod was separated with its R-enantiomer efficiently. Their average recoveries were 99.4 % and 96.2 %, with RSDs of 0.61% and 8.1%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2015年第1期52-54,共3页
Chinese Journal of Pharmaceuticals
基金
河北省科技支撑计划项目(13272614和12272604)
河北省自然科学基金资助项目(H2012206125)
河北省教育厅青年基金项目(Q2012028)
关键词
萘普西诺
手性固定相
手性分离
对映体
naproxcinod
chiral stationary phase
chiral separation
enantiomer
