期刊文献+

地奥心血康胶囊中甾体皂苷类成分的HPLC-ELSD指纹图谱 被引量:2

HPLC-ELSD Fingerprint of Steroid Saponins from Di'aoxinxuekang Capsules
原文传递
导出
摘要 建立了地奥心血康胶囊中甾体皂苷类成分的高效液相色谱指纹图谱。采用Inersil ODS-3 C18柱,以乙腈:0.1%甲酸为流动相,梯度洗脱,使用蒸发光散射检测器检测。共检测11批地舆心血康胶囊,建立其甾体皂苷成分指纹图谱的共有模式,相似度为0.934~0.998。确定8个共有峰,并利用对照品对照法指认其中的2个共有峰成分,即原薯蓣皂苷和薯蓣皂苷。 The fingerprint of steroid saponins from Di'aoxinxuekang capsules was established by HPLC-ELSD method, An Inersil ODS-3 column was used, with the mobile phase of acetonitrile :0.1% formic acid by gradient elution, with the application of evaporative light scattering detector (ELSD). The common pattern fingerprint of steroid saponins was established after examining 11 batches of Di'aoxinxuekang capsules, and their similarities were 0.934 - 0.998. There were 8 common peaks, in which two of them were identified as protodioscin and dioscin using the reference compounds.
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2015年第1期65-67,共3页 Chinese Journal of Pharmaceuticals
关键词 地奥心血康胶囊 甾体皂苷 高效液相色谱.蒸发光散射测定法 指纹图谱 Di'aoxinxuekang capsule steroid saponin HPLC-ELSD fingerprint
  • 相关文献

参考文献4

二级参考文献16

  • 1刘忠荣,邹文俊,王若竹,周正质.地奥心血康十年临床应用概述及疗效分析[J].中国医药学报,2004,19(10):620-622. 被引量:25
  • 2刘遂心,孙明,李彤.缺氧对心肌细胞内游离钙离子浓度和SERCA2表达的影响及薯蓣皂甙的干预作用[J].中华心血管病杂志,2004,32(9):841-843. 被引量:17
  • 3马远涛,赵婉,拓磊,石峰,孙文基.HPLC-ELSD法测定地奥心血康胶囊中薯蓣皂苷的含量[J].药物分析杂志,2006,26(6):823-825. 被引量:4
  • 4ChP(中国药典).2005.Vol.I(一部):429.
  • 5I.IU Chun- Zhao,ZHOU Hua- Ying, YAN Qiong. Fingerprint analysis of Dioscorea nipponica by high - performance liquid chromatography with evaporative light scattering detection. Analytica Chimica Acta ,2007,582:61.
  • 6LIU Zhong-rong(刘忠荣),HUANG Huang(黄璜).Use of diosgenin for producing a medicine for treating myocardial ischemia, myocardial infarction angina pectoris(薯蓣皂苷元在制备治疗心肌缺血、心绞痛和心肌梗死的药物中的用途),CN1187055C,2005-02-02.
  • 7中国药典[S].2010年版.一部.39-40,189,32.
  • 8Curtis M J, Walker M J. Quantification of arrhythmias using scoring systems: an examination of seven scores in an in vivo model of regional myocardial ischemia [J]. Cardiovasc Res, 1988, 22(9): 656-665.
  • 9Hagar J M, Hale S L, Kloner R A. Effect of preconditioning ischemia on reperfusion arrhythmias after coronary artery occlusion and reperfusion in the rat [J]. CirRes, 1991, 68(1) : 61-68.
  • 10Nitobe J, Yamaguchi S, Okuyama M, et al. Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes [J]. CardiovascRes, 2003, 57(1):119-128.

共引文献39

同被引文献24

引证文献2

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部