半夏泻心汤合四逆散治疗反流性食管炎临床观察

Combination of “Banxia Xiexin Decoction”and “Sini Powder”for the treatment of reflux esophagitis

目的观察半夏泻心汤合四逆散治疗反流性食管炎的临床疗效。方法将139例反流性食管炎患者随机分为治疗组(70例)与对照组(69例)。对照组予奥美拉唑及多潘立酮治疗,治疗组予半夏泻心汤合四逆散治疗。两组疗程均为3个月,观察内镜疗效及复发率,比较中医证候积分的变化情况。结果 1治疗组、对照组总有效率分别为85.71%和60.87%;组间内镜疗效比较,差异有统计学意义(P<0.05)。2治疗前后组内比较,两组各分项证候积分及总分差异均有统计学意义(P<0.05);组间治疗后比较,胸骨后或心窝部烧灼样疼痛、泛酸、嗳气、烧心、口苦、口干证候积分及总分差异有统计学意义(P<0.05)。3治疗组复发率为15.15%,对照组复发率为38.10%;两组复发率比较,差异有统计学意义(P<0.05)。结论半夏泻心汤合四逆散治疗反流性食管炎,可显著缓解临床症状,且复发率较低。

Objective To observe the clinical efficacy of ＂Banxia Xiexin Decoction＂ and ＂Sini Powder＂ in treating reflux esophagitis. Methods One hundred and thirty-nine eases with flux esophagitis were randomly divided into treatment group and control group. Control group in which 69 eases were treated with omeprazole and domperidone, and treatment group in which 70 cases were treated with ＂ Banxia Xiexin Decoction＂ and ＂Sini Powder＂ , with the course of 3 months. The curative effect and recurrence rate were observed and the TCM symptom scores were compared. Results （1）The total effective rate was 85.71% in the treatment group and 60.87% in the control group, with a difference between the two groups （P 〈0.05）. （2） In both groups, there were significant differences in the symptom scores and the total scores after treatment （P 〈0.05 ）; after treatment, there were significant in scores of symptoms such as pain, acid regurgitation, helehing, heartburn, bitter taste, dry mouth in preeordium and substernal parts between the two groups （P 〈0.05）. （3） The reeurrence rate was 15.15% in the treatment group and 38.10% in the control group, with a difference between the two groups （P 〈0.05 ）. Conclusion Combined ＂Banxia Xiexin Decoction＂ and ＂Sini Powder＂ can release the clinical symptoms, and with low recurrence rate for the treatment reflux esophagitis.