莫沙必利对功能性消化不良及近端胃舒张和胃排空功能的疗效研究

Study of the curative effect of mosapride on functional dyspepsia and proximal stomach diastolic and gastric emptying

目的探讨莫沙必利治疗功能性消化不良(FD)及近端胃舒张和胃排空功能的临床疗效。方法选择在该院治疗的FD患者102例,随机分为莫沙必利组(观察组)和吗丁啉多潘立酮片组(对照组)各51例,观察两组的临床疗效,采用LOGIQ-GE-200型诊断仪检测治疗前、后近端胃舒张和胃排空功能。结果观察组临床有效率为86.27%,明显高于对照组的64.71%,两组比较差异有统计学意义(P<0.05);观察组胃底气体评分和近端胃排空率均显著优于对照组(P<0.05);观察组服药后近端胃排空明显优于对照组(P<0.05);观察组不良反应发生率为3.9%,与对照组比较差异无统计学意义(P>0.05)。结论莫沙必利治疗FD临床效果优于吗丁琳,且能显著改善患者的近端胃舒张以及胃排空功能。

Objective To investigate mosapride in the treatment of functional dyspepsia（FD） and its effect on proximal stomach and gastric emptying function .Methods One hundred and two patients diagnosed of functional dyspepsia in our hospital were ran‐domly divided into observation group （with treatment of mosapride） and control group（with treatment of domperidone） ,and 51 ca‐ses were in each group .The clinical efficacy was observed ,and the LOGIQ‐GE2000 diagnostic apparatus were used to detect the de‐termination of proximal stomach and gastric emptying function before and after treatment .Results The clinical effective rate of the observation group was 86 .27% ,significantly higher than that of the control group（64 .71% ） .The difference was statistically signif‐icant between them（P0 .05） .Conclusion Mosapride in treatment of functional dyspepsia is better than domperi‐done ,and it could significantly improve the patient′s proximal stomach and the function of gastric motility .