肺功能非特异性表现120例临床分析

The characteristics and clinical manifestation of 120 subjects with non-specific pattern of pulmonary function tests

目的对肺功能非特异性表现(NSP)患者的临床特点进行研究,为其临床研究提供可参考依据。方法选择2013年1月至2014年6月青岛经济技术开发区第一人民医院行肺功能检查的120例受试者作为研究对象,根据肺功能表现分为NSP组(n=20)与肺功能正常组(n=100),详细记录其肺功能指标,对其临床特点进行分析。并筛选出NSP发生的相关因素,应用Logistic回归分析进行多因素回归分析。结果正常组肺功能指标第一秒肺呼气容积(FEVl)、肺活量(VC)、肺总量(TLC)、用力肺活量(FVC)、最大自主通气量(MVV)、FEVl/FVC均明显高于NSP组,而RV/TCL低于NSP组,差异均有统计学意义(P<0.05)。NSP组患者的临床可表现为阻塞性和(或)限制性疾病,但9例患者无肺部疾病。单因素分析显示NSP组年龄、BMI、吸烟史、吸烟量、阻塞性疾病、限制性疾病均明显高于正常组,两组比较差异有统计学意义(P<0.05)。多因素分析显示年龄大、BMI高、既往吸烟史、存在阻塞性疾病及限制性疾病是NSP发生的独立危险因素(P<0.05)。结论高龄、吸烟、肥胖可增加NSP发生的风险,临床上NSP可表现为阻塞性及限制性通气功能障碍的特点,在临床实际中需要积极鉴别。

Objective To analyze the characteristics of pulmonary function and the clinical significance of non‐specific pattern （NSP） ,and provide basis for the clinical research .Methods A total of 120 pulmonary function tests of adult patients from January 2013 to June 2014 were selected and divided into NSP group（n=20） and normal lung function group（n=100） according to their lung function behavior .The pulmonary function test results ,clinical diagnosis and radiological manifestations were analyzed .The relevant factors affecting NSP occurred were selected and logistic regression analysis was used to analyze multiple factors .Results The FEVl ,VC ,TLC ,FVC ,MVV and FEVl/FVC in normal group were significantly higher than that of NSP group and the RV/TCL was lower than NSP group ,the difference was statistically significant （P〈0 .05） .Patients in NSP group were with obstructive and （or） restrictive clinical manifestations .There were 9 patients were without lung disease .Univariate analysis showed that age , BMI ,smoking history ,smoking ,obstructive diseases ,and restrictive disease in NSP group were significantly higher than that in nor‐mal group ,the difference were statistically significant （P〈0 .05） .Multivariate analysis showed that age ,BMI ,history of smoking , obstructive diseases and restrictive disease were independent risk factors for NSP （P〈0 .05） .Conclusion Old age ,smoking and o‐besity could increase the incidence rate of NSP .The clinical characteristics include obstructive and restrictive ventilation defects ,and need to be identified positively .