三亚地区新生儿唐氏综合征流行病学调查及相关发病因素研究

Epidemiological survey on related risk factors of newborn infant with Down′s syndrome in Sanya city

目的了解三亚地区活产婴儿唐氏综合征(DS)的发生率,并探讨其相关影响因素。方法将三亚地区住院分娩的新生儿共25 032例纳入调查对象,通过外周血染色体分析对临床疑似为DS的患儿进行确诊。同时收集患儿及其双亲的临床资料,计算该地区DS发生率,并分析各相关发病因素。结果该地区DS总的发生率为9.59/万,其中汉族为8.34/万,黎族为14.42/万;DS患儿母亲平均育龄为29.8岁,DS发生率随母龄增长呈上升趋势。患儿母亲孕前有毒物、药物等"暴露"史者占45.8%。结论三亚地区DS发生率较高,提高该地区妇女孕期唐氏筛查及产前诊断率十分必要。

Objective To investigate the incidence of live births with Down syndrome（DS） in Sanya city as well as to discuss the related risk factors .Methods The object of investigation was the 25 032 infants who were born in Sanya city ,then the children with clinical suspected of DS were confirmed by peripheral blood chromosome analysis .Meanwhile ,the clinical data of children and their parents were collected ,calculating the incidence of DS in this region and analyzing the related risk factors .Results In this region , the total incidence of DS was 0 .959‰ ,the incidences in the Han nationality and Li nationality were 0 .834‰ ,1 .442‰ respectively . The mean age of DS children′s mother was 29 .8 years old ,and the incidence of DS increased as their mother grew older .Before pregnancy ,DS children′s mother who had an exposure history of toxicant and drugs accounted for 45 .8% .Conclusion The inci‐dence of DS in Sanya is quite high ,so it is extremely essential to strengthen the women′s pregnancy Down syndrome screening and improve the prenatal diagnosis in this region .