三种治疗方法对患者脑卒中后抑郁疗效的比较

Comparative study of effects of three treatment methods for post-stroke depression

目的:比较常规治疗、艾司西酞普兰及艾司西酞普兰联合认知行为治疗三种不同治疗方法对脑卒中后抑郁的抑郁症状及神经功能康复的疗效。方法:90例脑卒中后抑郁患者随机分为三组,分别为对照组、抗抑郁药组(艾司西酞普兰治疗组)及联合治疗组(艾司西酞普兰联合认知行为治疗组),分别于治疗前及治疗后8周用汉密尔顿抑郁量表(HAMA)和日常生活能力Barthel指数(BI)进行评定。结果:抗抑郁药组及联合治疗组在8周后的抑郁程度及日常生活能力均有所改善,其中以联合治疗组改善更明显。结论:艾司西酞普兰及艾司西酞普兰联合认知行为治疗均能改善脑卒中后抑郁的抑郁症状及日常生活能力,尤以艾司西酞普兰联合认知行为治疗效果更佳。

Objective：To compare effects of conventional therapy, Escitalopram and Escitalopram combined with cognitive be-havioral therapy on depression symptoms and nerve functional rehabilitation in post-stroke depression. Methods：A total of 90 patients with post-stroke depression were randomly divided into control group, Escitalopram group and Escitalopram combined with cognitive behavioral therapy group. These groups were evaluated with Hamilton depression scale （ HAMD） and activity of daily living （ ADL） （ BI） before and8 weeks after the treatment. Results：8 weeks after the treatment, the degree of depression was reduced and the daily living ability was improved in Escitalopram group and Escitalopram combined with cognitive behavioral therapy group. The escitalopram combined with cognitive-behavioral therapy group was more effective. Conclusions： Escitalopram and Escitalopram combined with cognitive behavioral therapy are in favor of not only controlling the post-stroke depression effectively, but also improving the daily living ability. The Escitalopram combined with cognitive behavioral therapy is more effective.