摘要
目的:观察卡维地洛对慢性心力衰竭患者血浆和肽素及内皮素(ET)的影响。方法:CHF患者190例,随机分为常规治疗组(94例)及卡维地洛组(96例,在常规治疗的基础上加用卡维地洛)。治疗6个月,比较治疗前后患者心功能变化及血浆和肽素和ET水平的差异。结果:卡维地洛组患者的总有效率明显高于常规治疗组(P<0.05),LVEDd及LVEF均较常规治疗组显著改善(P<0.05);血浆和肽素及ET水平与常规治疗组比较有显著下降(P<0.05)。结论:卡维地洛可以明显改善CHF患者的心功能,降低血浆和肽素及ET水平。
Objective：To investigate effects of carvedilol on plasma copeptin and endothelin （ ET） in the patients with chronic heart failure （ CHF） . Methods：190 patients with CHF were randomly divided into routine treatment group （ n=94 ） and carvedilol group （n=96, received carvedilol based on the routine treatment）. 6 months was regard as a course treatment. The cardiac function and the plasma copeptin and ET were observed and compared in all groups before and after treatment. Results：The total effective rate in carvedilol group was higher than that in routine treatment group （P〈0. 05）, and the LVEDd and LVEF were more significantly im-proved than routine treatment group （P〈0. 05）. There were more significant decreases in the plasma copeptin and ET levels in carve-dilol group than in routine treatment group （P〈0. 05）. Conclusions：Carvedilol can improve cardiac function of the CHF patients, and reduce the levels of plasma copeptin and ET.
出处
《中国民康医学》
2015年第2期49-51,共3页
Medical Journal of Chinese People’s Health
