无抽搐电休克治疗对精神分裂症患者认知功能的影响

Effects of no convulsions electric shock treatment on cognitive function in patients with schizophrenia

目的：探讨无抽搐电休克治疗（MECT）对精神分裂症患者的认知功能是否有影响。方法选取2012年1月-2014年4月收治的60例精神分裂症患者为研究对象,随机分成两组,每组各30例。观察组患者使用MECT合并新型抗精神病药物治疗,对照组患者单纯使用新型抗精神病药物治疗,分别行以中文版可重复神经心理状态测验（RBANS）、连线试验A和B、数字符号测试、阴性和阳性症状量表（PANSS）及副反应量表（TESS）等5个量表在入组时,第1周末,治疗完成后1周共3次对两组进行认知功能的评定,比较两组的差异。结果治疗第1周末：观察组RBANS各项及总分等均显著高于对照组（视觉空间结构相反）,PANSS各项及总分、TESS等均明显低于对照组（P﹤0.05）；对照组连线试验完成时间及错误次数显著低于观察组（P﹤0.05）。治疗后1周：观察组RBANS总分及各项均显著高于对照组,而PANSS总分及各项与TESS评分明显低于对照组（P﹤0.05）；对照组连线试验完成时间明显高于观察组（P﹤0.05）。结论无抽搐电休克治疗精神分裂症具有良好的治疗效果,但对患者认知功能存在可逆性损伤。

Objective To explore the effects of no convulsions electric shock treatment on cognitive function in patients with schizophrenia. Methods Sixty patients with schizophrenia from Jan 2012 to Apr 2014 were randomly divided into two groups. Observation group patients were treated with MECT and new anti-psychotic while control groups just with new anti-psychotic. The corresponding index were compared. Results The first treatment week： BANS scores of the observation group were significantly higher,while PANSS,TESS etc were significantly lower than the control group （vi-sual spatial structure was opposite） （P﹤0.05）; Connect test completion time and errors numbers of control group were significantly lower than the one of observation group（P﹤0.05）. One week after treatment：RBANS scores of observation group was significantly higher,while the PANSS, TESS scores were significantly lower than the control group（P﹤0.05）;Connect test completion time of control group were significantly higher than the one of observation group. Conclusion Schizophrenia patients with non-convulsive electric shock treatment,have a greatly recovery,but the presence of cogni-tive function exist reversible injury.