硫酸依替米星与头孢菌素联合治疗老年社区获得性肺炎的疗效评价

The solid effective evaluation of sulfate etimicin combined with cephalosporins for elderly patients with community-acquired pneumonia

目的：探讨硫酸依替米星与头孢菌素联合治疗老年社区获得性肺炎的实效性评价。方法选取2013年1月-2014年1月我院收治的88例CAP患者,将其分为观察组和对照组,各44例。观察组患者采用头孢菌素联合硫酸依替米星治疗,而对照组单独使用头孢菌素进行治疗,并从细菌学、患者的体温、咳嗽和咳痰、血象变化、X线胸片变化、肾毒性及耳毒性等方面进行观察分析。结果经过治疗后,观察组和对照组有效率分别为81.8%和59.1%,两组存在显著差异﹙χ^2=5.459,P=0.019〈0.05）；观察组和对照组的细菌清除率分别为77.3%和47.2%,差异有统计学意义﹙χ^2=8.194,P=0.004）；两组患者的肾毒性及耳毒性比较,差异有统计学意义﹙χ^2=4.201,P〈0.05；χ^2=3.382,P〈0.05）。结论硫酸依替米星和头孢菌素的联合使用对于细菌感染和病情的控制具有良好的治疗效果,是临床上可以考虑的一种有效手段,值得临床上大力推广。

Objective To investigate the solid effective evaluation of sulfate etimicin combined with cephalosporins for elderly patients with community-acquired pneumonia. Methods A total of 88 CAP patients were selected from January 2013 to January 2014 in our hospital were divided into observation group and control group with 44 patients respec-tively. Patients in observation group were treated with sulfate etimicin combined with cephalosporins while the control group was treat ed with cephalosporin alone. All patient’s bacteriology,patient＇s temperature,cough and sputum, changes in blood,X-ray changes, nephrotoxicity and ototoxicity were observed. Results After treatment, the efficient rate in the observation group was 81.8% while the efficient rate in control group was 59.1%.After compared between the two groups,it had a significant difference﹙χ2^=5.459,P=0.019〈0.05）. The observation group and bacterial clearance rate in the control group were 77.3% and 47.2% and the difference was statistically significant ﹙χ^2=8.194,P=0.004）. After the comparison of nephrotoxicity and ototoxicity between two groups, there was a significant difference ﹙χ^2=4.201,P〈0.05; χ^2=3.382,P〈0.05）. Conclusion Sulfate etimicin combined with cephalosporins has a good effect for the control of bacterial infection and the disease and it can be considered as a clinically and worthwhile effective means to promote clinical.