达英与二甲双胍联合对胰岛素抵抗合并多囊卵巢综合征患者临床疗效探究

Clinical Efficacy of Patients with Polycystic Ovary Syndrome Combined with Insulin Resistance Treated with Diane and Metformin

目的:探讨达英与二甲双胍联合对胰岛素抵抗合并多囊卵巢综合征(PCOS)患者的临床疗效,为临床提供参考。方法:选择笔者所在医院收治的84例PCOS患者,将所有患者随机分为A、B、C组,各28例。A、B、C组患者分别以二甲双胍、达英-35、二甲双胍联合达英-35服用。观察三组患者治疗前、治疗后的卵巢体积、卵泡刺激素(FSH)等指标。结果:A组治疗前后的卵巢体积、T、FINS、FPG及HOMA-IR比较,差异均有统计学意义(t=2.586、5.737、10.239、3.548、9.189,P<0.05)。B组治疗前后的卵巢体积、LH、T、FINS、FPG及HOMA-IR比较,差异均有统计学意义(t=2.564、4.921、19.411、10.532、2.842、12.558,P<0.05)。C组治疗前后的卵巢体积、LH、FSH、T、FINS、FPG及HOMA-IR比较,差异均有统计学意义(t=2.561、7.070、4.257、34.610、12.720、6.623、20.805,P<0.05)。三组患者的卵巢体积、LH、T、HOMA-IR指标比较,差异均有统计学意义(Z=6.281、7.328、6.820、6.829,P<0.05)。三组月经恢复率、排卵率及妊娠率比较差异均有统计学意义(字2=12.349、6.921、5.927,P<0.05)。结论:二甲双胍联合达英-35对于胰岛素抵抗合并多囊卵巢综合征疗效显著。

Objective：To investigate the clinical efficacy of patients with polycystic ovary syndrome combined with insulin resistance treated with Diane and Metformin.Method：84 patients with polycystic ovary syndrome combined with insulin resistance were chosen in our hospital to receive treatment,they were divided into three groups,28 patients in each group.The group A,group B and group C were treated with Metformin,Diane-35,Diane-35 combined with Metformin.The ovarian volume,follicle stimulating hormone（FSH） and other indicators in three groups of patients before and after treatment were observed.Result：Before and after treatment,the ovarian volume,T,FINS,FPG and HOMA-IR of group A were compared,the differences were statistically significant（t=2.586,5.737,10.239,3.548,9.189,P〈0.05）.Before and after treatment,the ovarian volume,LH,T,FINS,FPG and HOMA-IR of group B were compared,the differences were statistically significant（t=2.564,4.921,19.411,10.532,2.842,12.558,P〈0.05）.Before and after treatment,the ovarian volume,LH,FSH,T,FINS,FPG and HOMA-IR of group C were compared,the differences was statistically significant（t=2.561,7.070,4.257,34.610,12.720,6.623,20.805,P〈0.05）.The ovarian volume,LH,T,HOMA-IR index of three groups,the differences were statistically significant（Z=6.281,7.328,6.820,6.829,P〈0.05）.There were statistical differences in the recovery rate of menstruation,ovulation rate and pregnancy rate among the three groups（χ^2=12.349,6.921,5.927,P〈0.05）.Conclusion：The efficacy of insulin resistance in polycystic ovary syndrome treated with Diane-35 combined with Metformin is significant.