康爱保生中药制剂治疗艾滋病临床疗效分析

Analysis on Clinical Effects of Kangaibaosheng Preparations on HIV/AIDS

目的分析康爱保生中药制剂治疗HIV/AIDS的临床疗效。方法收集2005年12月-2010年3月云南各地医疗机构服用康爱保生制剂且未行HAART治疗的HIV/AIDS病例1038例,分析治疗前后的临床症状体征评分、卡洛夫斯基评分、CD4计数、HIV-RNA载量、血常规、肝肾功等指标。结果临床症状体征评分：总积分治疗后各时点均较治疗前下降（P〈0.01）,发热、咳嗽、乏力、纳呆、腹泻、呕吐、气短胸闷、自汗、盗汗、恶心、脱发、头疼、腹疼、关节疼、腰疼、皮肤瘙痒、月经失常（女性）、皮疹等单项症状评分均下降（P〈0.05）。卡洛夫斯基评分：治疗后各时点均较治疗前上升（P〈0.01）。CD4计数：据入组CD4分层：1≥350个/μL：治疗后各时点均下降（P〈0.05）;2201~349个/μL：治疗后各时点均上升（P〈0.05）;3≤200个/μL：第6月上升（P〈0.01）。病毒载量：第2次检测值与第1次相比上升（P〈0.05）。安全性指标：血小板计数轻微下降,其余指标治疗前后差异均无统计学意义。结论康爱保生制剂能改善艾滋病临床症状和生存质量,对CD4水平偏低者有一定稳定和提高免疫功能的作用,但CD4偏高者仍有下降。

Objective To analyze the clinical effect of Kangaibaosheng Traditional Chinese Medicine（TCM）preparations on HIV/AIDS. Methods A total of 1038 HIV/AIDS patients,who took Kangaibaosheng preparations without HAART treatment during March 2010 to December 2005 in medical institutions across Yunnan,were collected. Their clinical symptom scores,Karnovsky scores,CD4 counts,HIV-RNA loads,blood routine parameters,liver and kidney functions and other indexes were analyzed before and after treatment. Results Clinical sympptom score：after treatment,the total score at each time point decreased（P0.01）,and the score of each individual symptom,such as fever,cough,fatigue,anorexia,diarrhea,emesis,shortness of breath,chest distress,spontaneous sweating,night sweating,nausea,hair loss,headache,abdominal pain,joint pain,back pain,itchy skin,menstrual disorder（female） and skin rash,declined（P〈0.05）. Karnovsky score：after treatment,the Karnovsky score at each time point increased（P〈0.01）. CD4 count：according to CD4 hierarchy of enrolled patients：（1）≥350/μL：the CD4 count after treatment at each time point decreased（P〈0.05）;（2）（201~349）/μL：the CD4 count after treatment at each time point increased（P〈0.05）;（3）≤200/μL：the CD4 count increased in the sixth month after treatment（P〈0.01）. Viral load：there was no statistically significant difference between the first and the second detection values（P〈0.05）. Security index：platelet count declined slightly,and the differences for other security indexes before and after treatment were not statistically significant. Conclusions Kangaibaosheng preparations can improve clinical symptoms and life quality of HIV/AIDS patients,and promote or stabilize their immune functions;for enrolled patients whose CD4 levels were different,Kangaibaosheng preparations have different curative effects.