摘要
目的探讨房颤患者血清D-二聚体、B型钠尿肽水平及其对血栓形成的预测作用。方法房颤患者55例,按治疗期间是否发生左心房血栓及外周动脉血栓栓塞并发症分为血栓形成组（25例）和非血栓组（30例）,比较两组患者血栓形成前的血清D-二聚体、钠尿肽、C反应蛋白（CRP）水平,以及凝血酶原时间（PT）、活化部分凝血酶原时间（APTT）,左心房内径（LAD）、左室射血分数（LVEF）、左心室舒张期内径（LVEDD）。结果血栓形成组血栓形成之前的血清D-二聚体、钠尿肽、CRP、LAD、LVEDD、PT、APTT指标均显著高于非血栓组（P〈0.05）,血栓形成之前的LVEF低于非血栓组（P〈0.05）。血清D-二聚体的ROC曲线下面积为0.933（95%的可信区间0.872～0.993,P〈0.001）。血清钠尿肽的ROC曲线下面积为0.842（95%的可信区间0.741～0.843,P〈0.001）。结论血清D-二聚体、钠尿肽水平,可以作为预测房颤患者血栓形成的指标,血清D-二聚体对血栓形成的预测价值高于血清钠尿肽。
Objective To investigate serum D-dimer,natriureticpeptide levels and their roles in prediction of thrombosis among patients with atrial fibrillation（ AF）. Methods Fifty-five AF patients were divided into thrombosis group（ n = 25） and non-thrombosis group（ n = 30） according to whether they suffered from left atrial thrombosis and peripheral arterial thromboembolic complications or not. The D-dimer,natriureticpeptide and C reactive protein（ CRP）levels,prothrombin time（ PT）,activated partial prothrombin time（ APTT）,left atrial diameter（ LAD）,left ventricular ejection fraction（ LVEF）,left ventricular diastolic diameter（ LVEDD） were compared between two groups. Results Before thrombosis,the levels of D-dimer,natriureticpeptide and CRP,LAD,LVEDD,PT,APTT in the thrombosis group were significantly higher than those in the non-thrombosis group（ P〈0. 05）,LVEF in the thrombosis group was lower than that in the non-thrombosis group（ P〈0. 05）. The value of area under receiver operating characteristic（ ROC）curve of serum D-dimer was 0. 933[95% confidence interval（ CI） 0. 872- 0. 993,P〈0. 001]. The value of area under ROC curve of serum natriureticpeptide was 0. 842（ 95% CI 0. 741- 0. 843,P〈0. 001）. Conclusion Serum levels of D-dimer and natriureticpeptide can be used as the indexes for predicting the thrombosis in AF patients. Serum D-dimer is more valuable in the prediction of thrombosis compared with serum natriureticpeptide.
出处
《广西医学》
CAS
2014年第12期1754-1756,共3页
Guangxi Medical Journal
