益气清肺汤对老年晚期非小细胞肺癌患者免疫功能的影响

Impacts of Yiqi Qingfei Decoction on Immune Function of Elderly Terminal Patients with Non-Small Cell Lung Cancer

目的:观察益气清肺汤对老年晚期非小细胞肺癌患者免疫功能的影响。方法:将60例患者随机分为治疗组和对照组各30例,两组均采用相同化疗方案治疗,21d为1个周期,2个周期评价疗效。治疗组在化疗前2d加用益气清肺汤治疗。21d为1个疗程,2个疗程评价疗效。观察两组治疗后中医临床证候变化、免疫功能及不良反应变化。结果:两组中医临床证候变化比较,治疗组与对照组总改善率分别为83.3%和60.0%(P<0.05);两组治疗前后免疫功能比较,2个周期化疗后,对照组CD4+、CD4+/CD8+水平明显下降(P<0.05);而治疗组CD3+、CD4+、CD4+/CD8+水平较化化疗前有所增加(P<0.05)。两组组间比较,化疗后治疗组CD4+、CD4+/CD8+水平较对照组高(P<0.05)。两组不良反应比较,治疗组低于对照组(P<0.05)。结论:益气清肺汤联合化疗治疗老年晚期非小细胞肺癌具有改善中医临床证候、免疫功能、减轻不良反应,提高生活质量,延长生存期。

Objective： To observe the impacts of Yiqi Qingfei Decoction on immune function of elderly terminal patients of non-small cell lung cancer. Methods：60 patients were randomly divided into Treatment Group（30 cases） and Control Group（30 cases）. The two groups were adopted the same program of chemotherapy, with 21 days one period and 2 periods were required to evaluate effects. For the treatment group, Yiqi Qingfei Decoction was taken 2 days before chemotherapy, with 21 days one period and 2 periods were required to evaluate effects. The changes of symptoms in Chinese medicine, immune function and adverse reactions of patients of both groups were observed. Results： The improvement rate of symptoms in Chinese medicine of both groups were 83.3%and 60.0%respectively （P〈0.05） The immune function was compared before and after treatment in two groups. After two periods of chemotherapy,CD4^＋ and CD4^＋/CD8 levels decreased apparently in the control group （P〈0.05）, while the levels of CD3^＋、CD4^＋ and CD4^＋/CD8 all increased compared with those before treatment in the treatment group（P〈0.05）. For the comparison between the two groups after the treatment, the levels of CD4^＋ and CD4^＋/CD8 in the treatment group were higher than those in the control group（P〈0.05）.In comparison of adverse reactions between two groups, those of the treatment group was lower than in the control group（P〈0.05）.Conclusion： Yiqi Qingfei Decoction combined with chemotherapy can relieve clinical symptoms, improve immune function, reduce adverse reactions, enhance life quality and prolong life span of the patients with NSCLC at the late stage.