A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic ketene aminals and Konevenagel adducts formed by phthalic anhydride and ethyl cyanacetate

A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic ketene aminals and Konevenagel adducts formed by phthalic anhydride and ethyl cyanacetate

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摘要 An efficient synthetic pathway to 2-oxo-1,2-dihydropyridine-fused 1,3-diaza heterocycles from heterocyclic ketene aminals,phathalic anhydride and ethyl cyanacetate was established.This protocol involved aza-ene reaction/imine-enamine tautomerization/enamine-ester exchange/ring-opening reaction sequence. An efficient synthetic pathway to 2-oxo-1,2-dihydropyridine-fused 1,3-diaza heterocycles from heterocyclic ketene aminals,phathalic anhydride and ethyl cyanacetate was established.This protocol involved aza-ene reaction/imine-enamine tautomerization/enamine-ester exchange/ring-opening reaction sequence.

作者 Min-Ming Zou Feng-Juan Zhu Xue Tian Li-Ping Ren Xu-Sheng Shao Zhong Li

机构地区 Shanghai Key Laboratory of Chemical Biology

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2014年第12期1515-1519,共5页 中国化学快报（英文版）

基金 financial supported by National Natural Science Foundation of China(No.21372079) National High Technology Research Development Program of China(863 Program,No. 2011AA10A207) Shanghai Pujiang Program(No.14PJD012) Key Projects in the National Science & Technology Pillar Program(No. 2011BAE06B05) the Fundamental Research Funds for the Central Universities partly supported by Australia DC Foundation

关键词 Heterocyclic ketene aminals 2-Oxo-1 2-dihydropyridine 1 3-Diazaheterocycle Synthesis Heterocyclic ketene aminals 2-Oxo-1,2-dihydropyridine 1,3-Diazaheterocycle Synthesis

分类号 O626 [理学—有机化学] S816.7 [农业科学—饲料科学]

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共引文献4

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2014年第12期

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A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic ketene aminals and Konevenagel adducts formed by phthalic anhydride and ethyl cyanacetate

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