老年人垂体腺瘤的主要特征及治疗

The Main Characteristics and Treatments of Pituitary Adenoma in the Old People

回顾分析了80例经鼻蝶手术的垂体瘤病人,按年龄分老年组(≥60岁)21例,非老年组(<60岁)59例。统计各组病人头痛、视力障碍、功能性腺瘤及手术死亡所占的百分比,并进行两组间比较,用stata7.0软件统计分析,X^2检验,P<0.05有统计学意义。老年人头痛占47.62%,非老年组病人占44.06%,两组比较P=0.779;老年人视力障碍明显增多,占76.19%,非老年病人占45.76%,两组比较P=0.016;老年人功能性腺瘤明显减少,占28.57%,非老年组占59.32%,两组比较P=0.010。手术死亡均为0。结论:视力障碍是老年垂体瘤病人最主要症状,且垂体瘤主要为非功能性腺瘤,经鼻蝶垂体瘤切除术是安全的、有效的治疗方法。

80 patients underwent trans - sphenoidal resection of pituitary adenomas were retrospectively re- viewed and were devided into two groups： 21 patients in elderly （≥60） group and 59 patients in non -elderly（ 〈 60） group. The number of patients with headache, visual impaired symptoms and functioning pituitary adenoma were counted and the mortality caused by operation in each group was estimated as well. The results of two groups were compared and a chi - square test was used to compare the difference between two groups with stata 7.0. p 〈 0.05 indicates that there is statistically significant difference. Results 47.62% of patients in elderly group and 44.02% of patients in the other group were presented with headache （p =0.779）. More elder patients （76.19%） had visually impaired than other patients （45.76%）（p =0. 016）. However, we observed 28.57 % patients with functioning pituitary adenoma in elderly group, which was much less than that in non - elderly group （59.32%） （p = 0. 010）. Surgical mortality was zero. Conclusions There was a high incidence of visual impaired symptoms and no functioning pituitary adenoma in elderly patients. The surgical treatment of pituitary adenomas via the transsphe- noidal route will be a safe and effective procedure in elderly patients.