山楂叶总黄酮对糖尿病大鼠血糖、血脂代谢的影响

Effects of Hawthorn Leaves Flavonoids (HLF) on Fasting Blood Glucose and Serum Lipid in Diabetic Rats

目的观察不同剂量的山楂叶总黄酮(HLF)对糖尿病大鼠血糖、血脂代谢的影响。方法采用高糖高脂饲料喂养并腹腔注射链脲佐菌素(STZ)建立大鼠糖尿病模型,血糖≥16.7mmol/L,认为糖尿病模型建立成功。分别给予山楂叶总黄酮低剂量组(50mg/kg)、中剂量组(100mg/kg)、高剂量组(200mg/kg),观察山楂叶总黄酮对糖尿病大鼠体重、血糖及血脂等指标的作用。结果与正常组相比,模型组血糖、血脂成分甘油三脂(TG)、胆固醇(TC)水平明显升高(P<0.05),大鼠体重明显降低(P<0.01),提示糖尿病大鼠模型建立成功;给药6周后,给药组与模型组相比,山楂叶总黄酮50mg/kg、100mg/kg、200mg/kg组,血糖明显降低(P<0.05),大鼠体重明显改善(P<0.05);给予山楂叶总黄酮200mg/kg组,TG、TC明显减低(P<0.05)。结论山楂叶总黄酮具有降低糖尿病大鼠血糖血脂的作用,对糖尿病具有一定的防治功效。

Objective To investigate the effects of different dosages of hawthorn leaves flavonoids（ HLF） on blood glucose and serum lipid in diabetic rats. Methods The diabetic rat model was established by feeding high sugar and fat chow and intraperitoneal injection of streprozotocin（ STZ,40 mg / kg）. The body weight,fasting blood glucose（ FBG）,serum lipid level and visceral index were measured after the rats were treated with the different dosages of HLF（ 50 mg / kg、100mg / kg、200mg / kg）. Results Compared with the normal group,the levels of FBG,glycerin three greases（ TG） cholesterol（ TC） obviously increased in diabetic model group（ P〈0. 05）. However,the body weight obviously decreased in diabetic rats（ P〈0. 01）. After treatment of HLF for 6 weeks,three dosages（ 50 mg / kg,100 mg / kg,200 mg / kg） of HLF groups showed a significant decrease in FBG level and a significant increase in the body weight of rats（ P〈0. 05）,compared with the diabetic model group. HLF（ 200 mg / kg） significantly decreased serum TG and TC levels（ P〈0. 05）. Conclusion These results indicated that HLF can decrease the levels of blood glucose and serum lipid in diabetic rats,which provided a cue for the prevention and treatment of diabetes.