耐甲氧西林金黄色葡萄球菌感染临床发病特点与中医证候分布规律探析

Clinical characteristics of infection induced by methicillin-resistant staphylococcus aureus and its correlation with TCM syndrome

目的探讨耐甲氧西林金黄色葡萄球菌(MRSA)感染的临床发病特点与中医证候分布规律。方法记录首都医科大学附属北京中医医院2010—2012年MRSA感染患者104例的耐药情况,并对患者中医四诊资料进行统计,判断其中医证候要素,分析其分布情况。结果 MRSA感染患者均具有危险因素,1/3以上的患者伴有其他细菌、真菌感染,死亡率较高。中医证候出现的频率由高到低为虚实夹杂证、单纯实证、单纯虚证;虚证中出现频率由高到低为气虚证、阴虚证、阳虚证、血虚证;实证中出现频率由高到低为痰证、血瘀证、湿证、热毒证、气滞证、水饮证、燥邪证。结论 MRSA感染主要表现为虚实夹杂,邪实正虚贯穿于感染的整个病程。

Objective To explore the clinical characteristics of infection induced by methicillin-resistant staphylococcus aureus（ MRSA） and the distributed law of TCM syndromes. Methods The drug resistance condition of 104 cases with MRSA infection from 2010 to 2012 in Beijing TCM Hospital was recorded,and patients＇ information on TCM four diagnostic methods was arranged to evaluate syndrome factors of TCM and analyze the distribution. Methods Patients with MRSA infection all had dangerous factors,and more than one third of them were accompanied by bacterial and fungal infection,leading to high mortality. The frequency of TCM syndromes from high to low in turn was syndrome of intermingled deficiency and excess,excess syndrome and deficiency syndrome. The frequency of deficiency syndrome from high to low in turn was qi-deficiency syndrome, yin-deficiency syndrome, yang-deficiency syndrome,and blood-deficiency syndrome. The frequency of excess syndrome from high to low in turn was phlegm syndrome,bloodstasis syndrome, dampness syndrome, heat toxin syndrome, qi stagnation syndrome, water syndrome, dryness syndrome.Conclusion The infection induced by methicillin-resistant staphylococcus aureus was characterized with intermingled deficiency and excess,and evil-excess and heath-deficiency was throughout the whole course of infection.