摘要
Hydroxyethylidene diphosphonate(HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of188Re-HEDP.188Re-HEDP showed high focile uptake in normal mice(> 30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed tomography(SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.
Hydroxyethylidene diphosphonate（HEDP） was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of ^188Re-HEDP.^188Re-HEDP showed high focile uptake in normal mice（〉 30% ID/g at carrier co-injection） in BABLC/SPF mice. High quality single photon emission computed tomography（SPECT） image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.
基金
Supported by the National Natural Science Foundation of China(Nos.81071198,81172083 and 81371592)
Beijing Natural Science Foundation(No.7132040)
