加味甘麦大枣汤对更年期抑郁症患者血清单胺类神经递质的影响

Effects of modified Ganmai Dazao decoction on monoamine neurotransmitters in patients with climacteric depression

目的:观察、比较加味甘麦大枣汤和氟哌噻吨美利曲辛片对阳虚型更年期抑郁症患者的临床疗效及对血清单胺类神经递质的影响。方法:采用随机双盲对照法,将86例阳虚型抑郁症患者分为两组,治疗组口服加味甘麦大枣汤治疗,对照组口服氟哌噻吨美利曲辛片治疗,分别于治疗前、治疗2 w后、4 w后进行汉密尔顿抑郁量表(HAMD)评分,评价疗效,治疗前及用药4 w后测定患者血清单胺类神经递质5-羟色胺(5-HT)和去甲肾上腺素(NE)水平。结果:治疗后2 w、4 w与治疗前比较两组HAMD评分均显著降低(P<0.01),两组间同时段比较差异无统计学意义(P>0.05);经治疗后治疗组总有效率为88.4%,对照组总有效率为81.4%,两组病例治疗后总有效率比较差异无统计学意义(P>0.05),疗效相当。治疗4 w后两组血清5-HT、NE水平较治疗前均升高(P<0.01),两组比较差异无统计学意义(P>0.05)。结论:加味甘麦大枣汤可能通过调整抑郁症患者5-HT、NE水平干预抑郁症,改善临床症状,且疗效与氟哌噻吨美利曲辛相当。

Objective：To observe, compare clinical ettect of modified Ganmai Dazao decoction,flupentixol and melitraeen tablets on monoamine neurotransmitters in patients with climacteric depression of yang deficiency. Methods ： 86 cases were randomly divided into treatment group（treated with modified Ganmai Dazaotang decoction）and control group（treated with flupentixol and melitraeen tablets ）.The curative effcet was evaluated with Hamihon＇s depressive scale （HAMD）. The content of serotonin（5-HT）,norepinephrine（NE）in serum were detected before and ＇after the 4thweek of treatment. Results： Compare with pre-treatment,the score of HAMD decreased remarkably in both groups after 2＇h and 4＇h week of treatment （P〈0.01）. The total effective rate of treatment group was 88.4% and the total effective rate of control group was 81.4%, with insignificant difference between the two groups （P〉0.05）. After 4 weeks of treatment,the serum levels of 5-HT and NE increased in two groups （P〈0.01）. Conclusion：Modified Gamnai Dazao decoction can amendment clinical symptom through adjusting levels of 5-HT and NE of depression,and it＇s therapeutic effect is equivalence with Deanxit.