辛伐他汀对不同类型冠心病患者左心功能及脂联素、超敏C反应蛋白的影响

Effect of Simvastatin on left ventricular function in patients with different types of coronary heart disease and adiponectin, high-sensitivity C reactive protein

目的观察辛伐他汀对不同类型冠心病患者左心室功能及血清脂联素（APN）、超敏 C 反应蛋白（hs-CRP）含量的影响。方法将本院收治的119例冠心病患者分为观察组90例和对照组29例,观察组患者按照类型不同再分为稳定型心绞痛（SAP）组（32例）、不稳定型心绞痛（UAP）组（31例）和急性心肌梗死（AMI）组（27例）；对照组给予常规治疗,观察组在常规治疗基础上均给予辛伐他汀片20 mg 口服；治疗8周后比较各组患者的左心功能指标：左室舒张末期容积（LVEDV）、左室收缩末期容积（LVESV）和左室射血分数（LVEF）。ELISA法检测血清中 APN 和 hs-CRP 含量变化。结果疗程结束后,观察组的左心功能指标和血清指标含量变化均优于对照组,且差异有显著性（P ＜ 0.05）。SAP、UAP、AMI 三组患者的 LVEDV、LVESV减小,LVEF增大,血清中 APN含量增加、hs-CRP含量减少,与治疗前比较差异均有统计学意义（P＜ 0.05）；且 UAP组的LVEDV、hs-CRP减少值优于SAP组,AMI组的LVESV、hs-CRP减少值和APN增加值优于SAP组,且差异均有显著性（P＜ 0.05）。结论辛伐他汀可改善不同类型冠心病患者左室功能,其稳定动脉粥样硬化斑块的作用可能与调节血清 APN和 hs-CRP含量有关。

Obj ective][Obj ective]To observe the effect of Simvastatin on the left ventricular function in patients with different types of coronary heart disease and serum adiponectin （APN）,high sensitive C reactive protein （hs-CRP）content influence.[Methods]1 1 9 patients were randomly divided into the observation group 90 cases and control group 29 cases,the patients in observation group according to different types divided into stable angina pectoris （SAP）group （32 cases）,unstable angina pectoris （UAP）group （31 cases）and acute myocardial infarction （AMI）group （27 cases）.The control group was given conventional treatment,the ob-servation group based on routine treatment were given Simvastatin Tablets 20mg oral.Compared left ventricu-lar function index in each group after 8 weeks treatment,and detection the content changes of APN and hs-CRP in serum by ELISA.[Results]After treatment,the observation group in the indexes of left ventricular function and serum index content were both better than that of the control group （P 〈 0.05）.SAP,UAP, AMI three groups of patients with LVEDV,LVESV decreased,LVEF increased,serum APN content in-creased,the hs CRP content decreases,compared with before treatment differences were statistically signifi-cant （P〈 0.05）.UAP group,LVEDV、hs-CRP decrease value is superior to the SAP group.and AMI group LVESV,hs-CRP decrease value and added value of APN is superior to the SAP group,the differences were significant （P〈 0.05）.[Conclusions]Simvastatin can improve left ventricular function in patients with differ-ent types of coronary heart disease and its effect in atherosclerotic plaque stability may be related to regulating serum APN and hs-CRP levels.