益生菌联合益生元治疗老年慢性功能性便秘临床分析

Chinical analysis of probiotics combined with prebiotics in the treatment of elderly patients with chronic functional constipation

目的探讨益生菌(双歧杆菌四联活菌片)联合益生元(乳果糖口服溶液)治疗老年慢性功能性便秘(CFC)的有效性和安全性。方法将216例老年CFC患者半随机分为两组,A组110例给予益生菌联合益生元治疗,B组106例单用益生元治疗,疗程均为4周。对比两组的临床疗效和安全性。结果 A组显效83例,有效25例,无效2例。B组显效69例,有效21例,无效16例。A组疗效明显优于B组(P<0.05)。A、B两组12周复发率分别为7.4%和21.1%,不良反应发生率分别为8.2%和14.2%。结论益生菌联合益生元治疗老年CFC疗效优于单用益生元,并且不良反应较少。

Objective To explore the efficacy and safety of probiotics （bifidobacterium tetravaccine tablets ） combined with prebiotics （ lactulose oral liquid ） in the treatment of elderly patients with chronic functional constipation （CFC）.Methods Two hundred and sixteen elderly patients with CFC were randomly divided into two groups .One hundred and ten patients in group A were given probiotics combined with prebiotics , One hundred and six patients in group B were given prebiotics ,the treatment course lasted for 4 weeks.The clincal efficacy and safety of the two groups were compared.Results In group A,marked effect was found in 83 patients, effective in 25 patients,ineffective in 2 patients.In group B,marked effect in 69 patients,effective in 21 patients ,ineffective in 16 patients.The clinical effi-cacy in group A were better than those in group B （ P〈0.05 ） .During 12 weeks the recurrence rate in group A was 7.4%and that in group B was 21.1%（ P〈0.05 ） ,and the incidence of adverse reaction in group A was 8.2%and that in group B was 14.2%（ P〈0.05 ） .Conclusion The effect of probiotics combined with prebiotics is better than prebiotics alone in the treatment of elderly patients with CFC with less adverse drug reaction .