摘要
目的探讨普瑞巴林联合羟考酮治疗骨转移性癌痛的临床效果。方法将92名骨转移性癌痛患者随机分为两组。对照组单纯应用羟考酮,试验组给予普瑞巴林联合羟考酮。记录两组患者爆发痛发生人次、解救药用量及副作用,评估疼痛程度评分及总体生活质量。结果治疗后两组患者疼痛程度评分、平均解救药用量及生活质量总体评分较治疗前差异均有统计学意义(P<0.05)。结论普瑞巴林联合羟考酮治疗转移性骨癌痛比单纯应用羟考酮治疗转移性骨癌痛更安全有效。
Objective To analyze the clinical effect of the combined use of pregabalin and oxycodone on the pains caused by osseous metastatic carcinoma.Methods 92 patients with the pains caused by osseous metastatic carcinoma were randomly assigned into two groups.The contrast group was treated with oxycodone,while the experimental group was treated with the combined use of pregabalin and oxycodone.The frequency of the attacks of pain in patients,the dosage for relieving pain and the side effects were recorded.The degree of pains and the quality of patients＇ life were evaluated.Results There existed significant difference in the degree of pains,the dosage for relieving pain and the quality of patients＇ life between the two groups（P〈0.05）.Conclusion The combined use of pregabalin and oxycodone can produce good clinical effect on the pains caused by osseous metastatic carcinoma.
出处
《山东医学高等专科学校学报》
2014年第6期429-431,共3页
Journal of Shandong Medical College
关键词
骨转移性癌痛
羟考酮
普瑞巴林
Osseous metastatic carcinoma
Oxycodone
Pregabalin
