快速康复外科与自然杀伤细胞活化机制的研究进展

Research progress on fast track surgery and activation mechanism of natural killer cell

快速康复外科(FTS)通过围手术期多学科综合措施的临床应用,可以降低应激反应,降低术后并发症发生率,增强患者免疫功能,从而促进患者术后快速恢复,缩短住院时间,临床优势明显。自然杀伤(NK)细胞被认为是机体抗病毒感染、抑肿瘤的第一道天然防线,在抗病毒、抗肿瘤、免疫调节等方面发挥重要的生物学作用。应激反应的强弱与NK细胞的活化存在一定关系,本文推测FTS与NK细胞活化有着相互联系,通过内环境细胞因子及其代谢激素水平的变化,从而间接或者直接激活NK细胞。

The clinical application of fast track surgery （FTS） is widely accepted, which reduces stress and postoperative complications incidence, enhances patient＇s immune function through the clinical application of multidisciplinary intervention, and thereby achieves a rapid postoperative recovery and shorter hospital stay. Natural killer （NK） cell, considered as the body＇s first-line resistance to viral infection and tumor, plays an important biological role against virus, tumor, and in immunomodulatory mechanism, et al. With the review of activation mechanism of NK cells, a certain relationship between the stress response and the activation of NK cells is found. Through reducing the body＇s stress response, FTS can produce a series of cytokines and metabolic hormone changes in the internal environment, thus indirectly or directly activating NK ceils.