聚（ADP-核糖）聚合酶-1与缺血性脑损伤

Poly （ADP-ribose） polymerase-1 and ischemic brain injury

聚（ADP-核糖）聚合酶-1[poly（ADP—ribose）polymerase-1，PARP-1]是一种广泛存在于真核细胞内的核酶，在维持基因组稳定和调节基因转录等多种生理学过程中发挥着重要作用。PARP-1在缺血性脑损伤后过度激活，而PARP-1基因敲除小鼠或PARP-1抑制剂能在多种脑缺血模型中减轻脑损伤。因此，PARP-1在缺血性脑损伤的病理生理学过程中发挥着重要作用。探讨PARP-1在脑缺血中的作用，有助于进一步认识卒中的病理生理学机制以及发现新的治疗靶点。

Poly （ADP-ribose） polymerase-1 （PARP-1） is a ribozyme that widely exists in the eukaryotic cells. It plays important roles in the maintenance of genomic stability and the regulation of gene transcription and other physiological processes. PARP-1 is overactivated after ischemic brain injury, and PARP-1 gene knockout mice or PARP-1 inhibitor can reduce brain injury in a variety of models of cerebral ischemia. Therefore, PARP-1 plays important roles in the pathophysiologic processes of ischemic brain injury. The investigation of the effect of PARP-1 in cerebral ischemia contributes to further understanding the patbophysiologic mechanism of stroke and finding a new theraoeutic target.