急性白血病研究热点：第56届美国血液学会年会报道

The hot topics of acute leukemia： reports in the 56th ASH annual meeting

第56届美国血液学会年会（ASH）在急性白血病领域主要对以下6个问题给予了关注：一系列临床研究对白血病前体细胞进行了探索性研究;急性髓系白血病（AML）化疗研究主要集中于大剂量柔红霉素的应用;AML的靶向治疗主要是酪氨酸激酶抑制剂（TKI）的应用;急性早幼粒细胞白血病（APL）治疗研究集中于砷剂的应用;异柠檬酸脱氢酶2（IDH2）抑制剂AG221和MDM2抑制剂RG7388是目前非常有上市前景的靶向治疗新药;嵌合抗原受体修饰的T细胞（CAR-T细胞）的免疫治疗是急性淋巴细胞白血病（ALL）领域的热点.

There are six main topics in acute leukemia at 56th （2014） American Society of Hematology annual meeting.The preleukemic cells were investigated in serial clinical trials.The application of High dose daunorbicin is the main topic in the area of acute myeloid leukemia （AML） chemotherapy.The application of tyrosine kinase inhibitors is the main topic in the area of target therapy of AML.The application of arsenic is the main topic in the area of acute promyelocytic leukemia （APL） treatment.AG221,an IDH2 inhibitor,and RG7388,MDM2 inhibitor,are promising target drugs for AML.CAR-T cellular immunotherapy is the hot topic in acute lymphoblastic leukemia （ALL）.