青蒿素类药物治疗间日疟的研究进展

Research progress of Artemisinin-based drug for treatment of Plasmodium vivax malaria

疟疾作为一种致死性很高的全球性寄生虫病,一直被全世界所关注,疟疾的控制也被列入全球三大公共卫生问题之一。由于长期抗疟药的使用,目前恶性疟原虫对主要抗疟药物普遍产生抗药性,青蒿素类药物是在氯喹、奎宁抗药性产生后的主要替代治疗药。而对于间日疟原虫引起的疟疾的治疗,却与恶性疟原虫大不相同,本文针对间日疟的青蒿素治疗现状及进展情况进行了综述。

As a high lethally rate of global parasite disease, malaria has been the world＇s attention, the control of malaria was one of the three major public health problems in the world. Due to the use of antimalarial drugs for a long time, p. falciparum has been resistant to major antimalarial drugs including ehloroquine and quinine. Artemisinin-based drugs are the main alternative medicine. Treatment of Plasmodium vivax malaria is very different from Pletsmodium falciparum malaria, and current situation and progress in artemisinin treatment of vivax malaria are reviewed in this paper.