广东省某市871例HIV/AIDS病人生存影响因素的回顾性队列研究

Retrospective cohort analysis of 871 HIV/AIDS patients in a city of Guangdong Province

目的利用艾滋病综合防治信息系统了解艾滋病病毒（HIV）感染者/艾滋病（AIDS）病人（简称HIV/AIDS病人）生存的影响因素。方法采用回顾性队列研究方法,了解HIV/AIDS病人被确证感染后的转归及相关情况。结果 HIV/AIDS病人被确证时的年龄是影响生存时间的重要因素[风险值（HR）=1.04,95%可信区间（CI）：1.01-1.06,P〈0.01]。是否接受抗病毒治疗（HR=0.10,95%CI：0.03-0.33,P〈0.01）及初次CD^＋_4T淋巴细胞计数分级则是影响HIV/AIDS病人生存的保护性因素（HR=0.69,95%CI：0.58-0.82,P〈0.01）,接受抗病毒治疗、初次CD＋4T淋巴细胞计数分级高的生存时间长,差异具有统计学意义。结论早发现、早治疗有利于提高HIV/AIDS病人的生存时间。

Objective To realize the influencing factors of survival in HIV/AIDS patients through information for comprehensive prevention and control of AIDS. Methods A retrospective cohort analysis was conducted on 871 HIV/AIDS patients in one city of Guangdong Province to investigate outcome and related condition of patients after confirmation of HIV infection. Results The age when patients confirmed HIV infection was an important factor influencing survival（HR：1.04, 95%CI：1.01-1.06, P〈0.01）. Accepting antiretroviral therapy （ART） （HR= 0. 10,95%CI：0.03-0.33, P〈0.01） and baseline CD_4^＋ T cell count（HR=0.69,95%CI：0.58-0.82, P〈0.01） were protective factors for survival of H1V/AIDS patients. The longer the ART and the higher the baseline CD_4 T cell counts, the longer the survival. Conclusion Early finding and treatment are useful to extend the life of HIV/ AIDS patients.