血管介入术抗菌药物预防应用临床研究

Clinical study of prophylactic use of antibiotics for vascular interventional surgery

目的探讨抗菌药物的预防应用对血管介入术后感染的影响,为临床合理应用抗菌药物提供参考。方法选取医院2010年1月-2013年6月386例进行血管介入术的住院患者作为研究对象,将其随机均等的分为观察组和对照组两组,各193例;观察组在手术前1h给予适量的抗菌药物预防,对照组不给于抗菌药物,直接进行手术;对比两组患者的一般情况、手术后的相关症状和感染的发生率。结果两组基本资料比较差异无统计学意义;对比观察组和对照组的相关症状发热、C-反应蛋白及中性粒细胞升高结果显示,差异无统计学意义;观察组和对照组接受血管介入术后患者的感染情况对比,观察组发生感染的患者有5例,感染率为2.59%,对照组感染的患者有6例,感染率为3.11%,两组比较差异无统计学意义。结论抗菌药物的预防应用对血管介入术后感染率方面的影响无相关性,因此在临床上没有必要预防性应用,在一定程度上可以降低抗菌药物的耐药性。

OBJECTIVE To explore the influence of prophylactic use of antibiotics on postoperative infections in patients undergoing vascular interventional surgery so as to provide guidance for reasonable clinical use of antibiotics.METHODS A total of 386 hospitalized patients who underwent the vascular interventional surgery from Jan 2010 to Jun 2013 were recruited as the study objects and randomly divided into the observation group and the control group,with 193 cases in each;the observation group was treated with appropriate dose of prophylactic antibiotics at 1hour before the surgery,while the control group received the surgery without being given any antibiotics;the general status,related symptoms,and incidence of infections were observed and compared between the two groups.RESULTS There was no significant difference in the baseline data between the two groups.As compared with related symptoms such as fever,proportion of elevated C-reactive protein,and elevated neutrophils,there was no significant difference between the observation group and the control group.As compared with the incidence of postoperative infections in the patients undergoing the vascular interventional surgery,it was 2.59%（5cases）in the observation group,3.11%（6cases）in the control group,there was no significant difference between the two groups.CONCLUSIONThe prophylactic use of antibiotics is not associated with the incidence of postoperative infections in the patients undergoing vascular interventional surgery,therefore,the antibiotics prophylaxis is not necessary in the hospital,and it can reduce the drug resistance to a certain extent.