肺炎支原体感染患儿消化系统损害的临床特点及危险因素分析

Clinical characteristics of digestive system damage of children with Mycoplasma pneumoniae infection and analysis of risk factors

目的探讨肺炎支原体感染患儿消化系统损害的临床特点及相关危险因素,为临床预防治疗消化系统损害提供参考。方法回顾性分析2012年3月-2014年3月收治的296例肺炎支原体感染患儿临床资料,分析总结患儿并发肺外消化系统损害的临床特点,并对发生消化系统损害的相关危险因素进行单因素以及多因素logistic回归分析。结果 296例肺炎支原体感染患儿中有145例并发肺外损害,发病率为48.9%,其中有48例为消化系统损害,占33.1%,其临床症状以恶心呕吐、腹痛腹泻最常见;多因素logistic回归分析显示,年龄、热程、发热程度、大环内酯类抗菌药物应用起始时间、C-反应蛋白、肺炎支原体抗体滴度升高与肺炎支原体感染患儿并发消化系统损害呈正相关(P<0.05)。结论肺炎支原体感染患儿肺外损害的发生率较高,以消化系统最常见;多种因素影响肺炎支原体感染患儿消化系统损害的发生,应尽早根据相关危险因素给予感染患儿临床干预以减少消化系统损伤的发生。

OBJECTIVE To explore the clinical characteristics of digestive system damage of children with Mycoplasma pneumoniae infection and analyze the related risk factors so as to provide guidance for clinical prevention and treatment of digestive system damage.METHODS The clinical data of 296 children with M.pneumoniaeinfection who were treated in the hospital from Mar 2012 to Mar 2014 were retrospectively analyzed,the clinical characteristics of the children complicated with digestive system damage were analyzed,and the univariate analysis and multivariate logistic regression analysis were performed for the related risk factors for the digestive system damage.RESULTS Of the 296 children with M.pneumoniaeinfection,145 were complicated with extrapulmonary damage,with the morbidity of 48.9%,including 48（33.1%）cases of digestive system damage;the nausea and vomiting and abdominal pain and diarrhea were the most common clinical symptoms.The multivariate logistic regression analysis indicated that the concurrent digestive system damage in the children with M.pneumoniae infection was positive correlated with the age,thermal history,fever,starting time of use of macrolides,C-reactive protein,and elevated M.pneumoniae antibody titers（P〈0.05）.CONCLUSION The incidence of extrapulmonary damage is high in the children with M.pneumoniaeinfection,and the digestive system damage is the most common.There are a variety of influencing factors for the digestive system damage in the children with M.pneumoniaeinfection.It is necessary to take clinical interventions to the children with infections according to the related risk factors so as to reduce the incidence of digestive system damage.