2型糖尿病同型半胱氨酸与踝肱指数分析

Relation of plasma homocysteine levels and ankle brachial index in type 2 diabetic patients

目的探讨血清同型半胱氨酸(Hcy)与踝肱指数(ABI)在评估糖尿病患者周围动脉病变(PAD)中的相关性。方法选择2011年8月至2012年6月厦门市第二医院收治的2型糖尿病患者204例,均测定血清Hcy及ABI,并根据Hcy水平分为A组(Hcy<15μmol/L,167例)和B组(Hcy≥15μmol/L,37例);根据ABI水平分为非PAD组(0.9<ABI≤1.3,140例)、PAD组(ABI≤0.9,19例)和动脉硬化组(ABI>1.3,45例),比较不同组间Hcy和ABI水平的变化情况。结果动脉硬化组患者血清Hcy最高,PAD组次之,非PAD组血清Hcy最低,三组两两比较,差异均有统计学意义(P<0.05);B组患者异常ABI的比率明显高于A组,差异有统计学意义(P<0.01)。结论血清Hcy与2型糖尿病PAD关系密切,有望成为糖尿病PAD的血清标志物。

Objective To investigate the correlation of homocysteine （Hcy） and ankle brachial index （ABI） in evalua-tion of diabetic peripheral artery disease. Methods ABI and homocysteine were measured in 204 Type 2 diabetic patients from Auguest 2011 to June 2012 in Xiamen No.2 Hospital. According to serum Hcy concentrations ,the patients were divided into group A （Hcy〈15μmol/L,167 cases）,and group B （Hcy≥15μmol/L,37 cases）.According to ABI,the patients were divided into non-PAD（0.9〈ABI≤1.30,140 cases）,PAD group（ABI≤0.9,19 cases）,and the atherosclerosis group（ABI〈1.3,45 cases）. Results The plasma serum Hcy concentrations in the atherosclerosis group was the highest,followed by PAD group,non-PAD group with the lowest plasma serum Hcy. The were statistical significance in difference （P〈0.05）. The incidence rate of abnormal ABI of group B were obviously higher that of the group A,whose difference had stastical significance（P〈0.01）. Conclusion The plasma Hcy is closely related to diabetic peripheral artery disease（PAD）,which may be a serum marker for predicting diabetic PAD.