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mTOR信号通路与肿瘤研究进展 被引量：11

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摘要 哺乳动物雷帕霉素靶蛋白（mTOR）是1991年从酵母中分离出的一种丝氨酸/苏氨酸蛋白激酶，是多条信号通路的关键蛋白分子，在体内参与多种细胞增殖、分化、自噬、凋亡及周期调控，是近年来在肿瘤领域的研究热点并已取得很大进展。本文就其与常见肿瘤的关系作一综述。
作者 陆建国 俞松
机构地区 遵义医学院附属医院
出处 《现代医药卫生》 2015年第2期199-202,共4页 Journal of Modern Medicine & Health
基金 国家自然科学基金资助项目(81160330) 贵州省省长资金资助项目(黔省专合字[2010]67号)
关键词 信号传导 肿瘤/病理学 基因 综述
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献48

  • 1Lai EY,Chen ZG,Zhou X,et al. DEPTOR expression negatively corre-lates with mTORCl activity and tumor progression in colorectal cancer[J].Asian Pac J Cancer Prev,2014,15(11) :4589-4594.
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  • 3Peterson TR,Laplante M,Thoreen CC,et al. DEPTOR is an mTOR inhi-bitor frequently overexpressed in multiple myeloma cells and required fortheir survival[J]. Cell,2009,137(5) ;873-886.
  • 4Yadav RB , Burgos P, Parker AW ,et al. mTOR direct interactions withRheb-GTPase and raptor : sub-cellular localization using fluorescence life-time imaging[J]. BMC Cell Biol,2013,14:3.
  • 5Toschi A,Lee E,Xu L,et al. Regulation of mTORCl and mTORC2 com-plex assembly by phosphatidic acid : competition with rapamycin[J]. MolCell Biol,2009,29(6) :1411-1420.
  • 6Sui T,Ma L,Bai X,et aJ. Resveratrol inhibits the phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathwayin the human chronic myeloid leukemia K562 cell line[J]. Oncol Lett,2014,7(6):2093-2098.
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二级参考文献60

  • 1唐吉云,张端莲,陕声国.皮肤血管瘤组织中细胞周期素E的阳性面积率和平均光密度的表达[J].数理医药学杂志,2006,19(5):459-461. 被引量：1
  • 2吕红琼,周林静,王平,张华.真核翻译起始因子eIF4E与恶性肿瘤的研究进展[J].实用肿瘤学杂志,2007,21(1):88-91. 被引量：5
  • 3Pisick E, Jagadeesh S, Salgia R. Receptor tyrosine kinases and inhibitors in lung cancer. Sci World J, 2004, 6(4): 589-604.
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  • 5Steelman LS, B ertrrand FE, McCubrey JA. The complexity of PTEN: mutation, marker and potential target for therapeutic intervention. Expert Opin Ther Targets, 2004, 8(6): 537-550.
  • 6Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Can, 2006. 6(9): 729-734.
  • 7Shaw RJ, Canfley LC. Ras, PI(3)K and roTOR signalling controls turnout cell growth. Nature, 2006, 441 (7092): 424-430.
  • 8Massion PP, Taflan PM, Shyr Y, et al. Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression. Am J Respir Crit Care Med, 2004, 170(10): 1088-1094.
  • 9Conde E, Angulo B, Tang M, et al. Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling. Clin Cancer Res, 2006, 12(3): 710-717.
  • 10Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science, 1997, 275 (5300): 628-630.

共引文献47

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引证文献11

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现代医药卫生
2015年 第2期

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